Rhabdomyosarcoma
  • 3% of Pediatric Cancer
  • Sites :
    • Most common site is Head and Neck ( Like bibcite Anna in PMH - She had Parotid Rhabdo ) : 40%
      • Parameningeal 25%
      • Orbit 9%
      • Nonparamenigeal 6%
    • GU 30%
    • Extremity 15%
    • Trunk 15%
  • Syndromes associated with Rhabdomyosarcoma :
    • Li-Fraumeni
    • Neurofibromatosis type I
    • Beckwith-Wiedmann
      • This syndrome is more associated with Wilm's Tumour
  • Histologic Types:
    • Embryonal ( 65% )
      • Orbit
      • Head and Neck
      • GU
      • OS 66% ( intermediate prognosis )
    • Alveolar ( 30% )
      • Adolescents
      • Extremity
      • Trunk
      • Retroperitoneum
      • OS 54% ( Poor prognosis )
    • Botyroid ( 10% )
      • Vagina
      • Bladder
      • Nasopharynx
      • Biliary Tract
      • 95% OS ( good prognosis )
      • LOH on 11p15.5
    • Undifferentiated ( 5% )
    • Spindle Cell ( <5% )
      • Paratesticular