Pathology In Cns Tumours

• WHO grade I
  • Low proliferative potential
  • Possibility of cure following surgery only
• WHO grade II
  • Infiltrating
  • Low in mitotic activity
  • Recur more frequently than grade I malignant tumors after local therapy
  • Some tumor types tend to progress to higher grades of malignancy
• WHO grade III
  • Evidence of malignancy
    • Nuclear atypia
    • Increased mitotic activity
    • Anaplastic histology
    • Infiltrative capacity
    • Usually treated with aggressive adjuvant therapy.
• WHO grade IV
  • Mitotically active
  • Necrosis-prone
  • Proliferation
  • Vascular invasion
  • Rapid preoperative and postoperative progression and fatal outcomes