Boost Vs No Boost Trial

EORTC Trial

  • 5569 patients
  • All lumpectomy+XRT 50 Gy.
    • Those w clear margins: 2 arms:
      • 16-Gy boost
        • Field—> Scar + 1.5cm
        • 5 and 10 yr local recurrence:
          • 4 and 6%
      • No Boost
        • 5 and 10 yr local recurrence:
            • 7 and 10%
  • All positive margins
    • Boost dose of 10 or 26 Gy
  • Severe fibrosis increased from 2% to 4%
  • Boost dose significantly reduced the 5-year LR rate from 7 to 4% for patients with a complete excision (P<0.001).
  • =<40year : The boost dose ==> LR 20 to 10% (P=0.002).
  • The 5-yr local control based on age:
    • <or=35 years: 82%
    • 36-40 years 85%
    • 41-50 years 92%
    • 51-60 years 96%
    • >60 years 97% (P<0.0001)