Aromatase Inhibitor
  • Mechanism of action
    • inhibits enzyme aromatase
      • Aromatase converts androgen to estrogen
        • That's why it is not appropriate in premenopausal women
          • Ovaries will increase aromatase production

MA-17 Trial

  • Extended endocrine therapy
  • Trial of 5 years AI after 5 years Tamoxifen
  • Significant decreased breast ca death and recurrence

Exemestane —> irreversible aromatase inactivator