All About Tamoxifen

Tamoxifen is a selective estrogen receptor modulator: ( SERM )

  • Estrogen agonist and antagonist properties depending on the individual target organ.
  • Antiestrogenic activity in breast tissue ==> reducing epithelial cell proliferation ==> chemopreventive agents
  • Estrogen-like effect in uterus
    • Raloxifene acts as an estrogen antagonist.

Benefits:

  • Decrease future breast Ca
  • Lowering blood cholesterol
  • Slowing bone loss
  • In breast cancer patients
    • 40% risk reduction for recurrence
    • 30% risk reduction from breast ca death

Risks:

  • Endometrial Ca (x2)
  • Stroke
  • Pulmonary embolism
  • DVT (x2)

Side Effects:

  • Hot flashes
  • Vaginal discharge
  • Sexual dysfunction
  • Menstural irregularities